Low-Intensity Focused Ultrasound.
Precision Therapy, Reimagined for Animals.
LIFU delivers targeted acoustic energy to specific tissues with 1mm precision; no surgery, no sedation, no mechanical trauma. It’s the most versatile therapeutic modality brought to animal health.
What is Low-Intensity Focused Ultrasound?
Technology by Openwater
Pelara LIFU utilizes focused ultrasound hardware and software from Openwater, a company specializing in programmable sound- and light-based medical technology. The platform delivers precise, noninvasive acoustic energy deep within tissue by concentrating ultrasound at a specific focal point, producing therapeutic effects through mechanical force rather than heat.
Acoustic radiation force
A sustained mechanical push at the focal point activates mechanosensitive ion channels in cells, triggering biological repair and neural modulation.
Acoustic microstreaming
Circular fluid motion near tissue interfaces increases cell membrane permeability, enhancing drug uptake and accelerating healing at the focal site.
Sonoporation
Transient nanopores (100–200nm) form in cell membranes, enabling targeted drug delivery of chemotherapeutics, antibodies, and biologics with precision impossible by IV alone.
No thermal damage
LIFU operates below 720 mW/cm², less than 1°C tissue heating. Healthy tissue surrounding the target is completely spared. Safe, reversible, repeatable
Modular & Configurable For Many Applications
Transmit Modules 64
64-Ch, synchronized, cascading tiles
Android Targeting App
Photogrammetry
Two Center Frequencies
Comprehensive blood work and microbiological analysis.
Open-Source Platform
GUI, 3D Slicer or Python Control
Pelara Patients
Applications Currently Being Researched
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Chronic Pain
Non-pharmacological relief for osteoarthritis, neuropathic, and post-surgical pain. Reduces reliance on NSAIDs and opioids.
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Cardiac neuromodulation
Non-invasive stellate ganglion modulation to reduce arrhythmias and ventricular dysfunction.
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Musculoskeletal
Accelerated soft tissue repair through mechanical signaling. Barn-ready, portable device for equine practitioners.
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Oncology
Direct tumor cell lysis and enhanced delivery of chemotherapeutics via sonoporation. Meaningful alternative to surgery.
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Neurology
Transcranial focused neuromodulation for refractory epilepsy and chronic neurological conditions.
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Immunotherapy
Local and systemic immune modulation to enhance cancer therapy outcomes and infectious disease response.
Pelara LIFU vs. the alternatives
Pelara is bringing LIFU to every clinic, every barn, every animal that needs it.